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Prevention of Hospital Infections by Intervention and Training

Healthcare-associated infections (HAI) are considered as adverse events occurring during care delivery in all types of healthcare settings. Among these, central line-related bloodstream infections (CRBSI) are particularly worrisome as they are associated with high morbidity and attributable mortality. During the past few years, there has been a remarkable proliferation of observational and interventional studies in the field of infection control reported in the literature. Many reports have demonstrated the benefit of (mostly) multimodal intervention strategies for the prevention of HAI, particularly CRBSI. Best practice guidelines and HAI prevention documents have been issued by a number of healthcare bodies and countries. As a step further, some countries have established mandatory outcome surveillance partially combined with public reporting. These variations are reflected in the results of the HELICS/HAI-Net surveillance and published data, which show marked differences of HAI and CRBSI rates between European countries. ________________________________________________________________________ The objective of PROHIBIT is to understand the variations of HAI prevention in Europe and to test the success of a CRBSI prevention strategy. The following questions are specifically addressed: ............................................................................................................ 1) who issues and updates guidelines and recommendations on infection control in Europe?; .................................................................................................................................... 2) what infection control activities (surveillance and/or prevention) are accepted and established by European hospitals?;.................................................................................................................................. 3) what are the facilitators and barriers for compliance with best practice?; .................................................................................................................................................... 4) what is the effectiveness of a transnational prevention programme in a set of hospitals with different cultural, financial, and healthcare backgrounds? ________________________________________________________________________ The project employs a mixed-methods approach within four scientific work packages combining the strengths of qualitative research, survey methods, and observational and experimental designs. Current guidelines and recommendations on HAI prevention have been systematically studied and a survey has been conducted among selected European hospitals. Factors interfering with the adoption and implementation of infection control practices will be determined using qualitative research among a set of hospitals participating in a multimodal intervention study to compare the effectiveness of hand hygiene or a strategy to improve the insertion and care of central venous catheters.
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